Ian Smith, chair of Infinity’s Audit Committee, is executive vice president, chief operating and chief financial officer at Vertex Pharmaceuticals Incorporated. He joined Vertex in November 2001. As Vertex’s Executive Vice President and Chief Financial Officer. Mr. Smith holds responsibility for core functions at Vertex, including Finance and Accounting, Investor Relations, Business Development, Information Systems and Worldwide Operations. Prior to joining Vertex, Mr. Smith served as a partner in the Life Science and Technology Practice Group of Ernst & Young LLP, an accounting firm, from 1999 to 2001. Mr. Smith is also a member of the Board of Directors of Acorda Therapeutics and Ophthotech Corporation and serves as the Chairman of the Audit Committee for Ophthotech. Mr. Smith received a B.A. with honors in Accounting and Finance from Manchester Metropolitan University, and Mr. Smith is a current member of the American Institute of Certified Public Accountants, the Institute of Chartered Accountants of England and Wales, and the Financial Executives Institute.